Insulin — Glargine — Half-Life, Dosing & Protocol Guide

Also known as: Lantus, Basaglar, Toujeo, Semglee, insulin glargine

Pharmacokinetics & Mechanism

Insulin glargine (Lantus/Basaglar/Toujeo) achieves peakless 24-hour basal coverage via two structural modifications: A21 Asn→Gly (prevents deamidation at isoelectric point) and two additional Arg residues at B-chain C-terminus (shifts isoelectric point from 5.4 to 6.7, enabling pH-4 solubility). At subcutaneous physiologic pH 7.4, the acidic formulation microprecipitates → slow re-dissolution over 24 hours with no pronounced peak. No traditional half-life applies — kinetics are depot-driven. Cannot be mixed with other insulins or administered IV.

Track Insulin — Glargine in Halflife

The Halflife app models your Insulin — Glargine concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.