Also known as: HGH Fragment 176-191, Tyr-hGH 177-191
AOD-9604 is a synthetic 16-amino-acid C-terminal HGH fragment (residues 177–191) with N-terminal tyrosine substitution. No human pharmacokinetic study has been published; the ~0.5h estimate derives from peptide size and rodent data (Heffernan et al. 2001). It activates β3-adrenergic lipolysis without binding the GH receptor or raising IGF-1. Clinical development was discontinued after Phase IIb failed to demonstrate significant weight loss versus placebo. The FDA has listed AOD-9604 as a bulk drug substance that may not be used in compounded preparations under Sections 503A and 503B.
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