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Recovery / Repair

PEG-MGF — Half-Life, Dosing & Protocol Guide

Also known as: Pegylated Mechano Growth Factor, IGF-1Ec E-peptide PEGylated

Preclinical · Goldspink, Exp Physiol — no published human PK study
Plasma Half-Life
~24h (PEGylated); native MGF ~5–7 min
Source: Goldspink, Exp Physiol — no published human PK study
Route
Subcutaneous / Intramuscular
Frequency
2–3× weekly
Dose Range
200–500mcg SC 2–3× weekly
Category
Recovery / Repair
⚠ No Published Human Pharmacokinetic Data
Half-life values are based on preclinical (animal) studies or community estimates only.

Pharmacokinetics & Mechanism

PEG-MGF is the PEGylated 24-amino-acid C-terminal E-domain of the IGF-1Ec splice variant. Native MGF E-peptide has an estimated half-life of 5–7 minutes; PEGylation extends this to approximately 24 hours by reducing renal filtration and proteolytic degradation. No human pharmacokinetic study has been published. The compound activates muscle satellite cells via a receptor distinct from IGF-1R, promoting proliferation and repair in mechanically loaded or damaged skeletal muscle — complementary to the IGF-1R anabolic pathway. WADA-prohibited under S2 (growth factors).

Track PEG-MGF in Halflife

The Halflife app models your PEG-MGF concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.

See your PEG-MGF curve live

Real-time pharmacokinetic model · Free iOS app

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See also: Full technical profile → All 45 compounds About the app