Thymosin Alpha-1 — Half-Life, Dosing & Protocol Guide

Also known as: Thymalfasin, Zadaxin, Tα1

Pharmacokinetics & Mechanism

Thymosin Alpha-1 (Tα1, Zadaxin/Thymalfasin) is a 28-amino-acid N-terminally acetylated thymic peptide with a subcutaneous half-life of approximately 2 hours, established in the Zadaxin prescribing label and Pichard et al. (PMID 10027483). It acts as a TLR2 and TLR9 agonist, restoring depressed T-cell, NK cell, and dendritic cell function. Approved in more than 35 countries for chronic hepatitis B and hepatitis C. Standard dosing: 1.6mg SC twice weekly. Over 11,000 subjects enrolled across 30+ published clinical trials. Not FDA-approved in the United States.

Track Thymosin Alpha-1 in Halflife

The Halflife app models your Thymosin Alpha-1 concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.