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Nootropic / Cognitive

Selank — Half-Life, Dosing & Protocol Guide

Also known as: Thr-Lys-Pro-Arg-Pro-Gly-Pro, tuftsin analog, TP-7

Preclinical · No published human PK data — rat degradation kinetics estima
Plasma Half-Life
~7–10 min plasma (rat)
Source: No published human PK data — rat degradation kinetics estimate
Route
Intranasal (primary); Subcutaneous (off-label)
Frequency
2–3× daily
Dose Range
250–500mcg intranasal 2–3× daily
Category
Nootropic / Cognitive
⚠ No Published Human Pharmacokinetic Data
Half-life values are based on preclinical (animal) studies or community estimates only.

Pharmacokinetics & Mechanism

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP-7) is a synthetic heptapeptide analog of tuftsin with an estimated rat plasma half-life of 7–10 minutes based on in vivo degradation studies. No human pharmacokinetic study has been published. Direct olfactory nerve delivery via intranasal administration provides extended CNS exposure beyond the short plasma half-life. Proposed mechanisms include GABA-A receptor modulation at the benzodiazepine binding site, enkephalinase inhibition, and serotonin/dopamine modulation. Produces anxiolytic effects without sedation, muscle relaxation, or dependence potential. Approved in Russia as Selank 0.15% nasal spray.

Track Selank in Halflife

The Halflife app models your Selank concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.

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Real-time pharmacokinetic model · Free iOS app

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See also: Full technical profile → All 45 compounds About the app