Also known as: ACTH 4-10 analog, Met-Glu-His-Phe-Pro-Gly-Pro
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide ACTH(4-10) analog with a rat plasma half-life of approximately 2–5 minutes due to N-terminal aminopeptidase cleavage. Its active metabolite Pro-Gly-Pro retains neurotrophin-modulating activity with an estimated CNS residence of 12–24 hours, explaining why functional effects persist far beyond plasma clearance. No human pharmacokinetic study has been published. Primary mechanisms include BDNF/NGF upregulation in hippocampus and cortex, dopamine/serotonin modulation, and enkephalinase inhibition. Approved only in Russia and CIS countries as 0.1% nasal spray.
The Halflife app models your Semax concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.