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TRT / Hormones

Oxytocin — Half-Life, Dosing & Protocol Guide

Also known as: Pitocin, Syntocinon, love hormone, OT

FDA-Approved · FDA NDA 018261 (Pitocin prescribing information)
Plasma Half-Life
~1–6 min (IV); ~30–60 min (SC estimate)
Source: FDA NDA 018261 (Pitocin prescribing information)
Route
IV infusion / IM (FDA-approved); SC / Intranasal (off-label)
Frequency
On-demand
Dose Range
FDA: 0.5–1 mU/min IV (obstetric)
Category
TRT / Hormones

Pharmacokinetics & Mechanism

Oxytocin (Pitocin/Syntocinon) has an IV plasma half-life of approximately 1–6 minutes per the FDA Pitocin prescribing information (NDA 018261), attributed to rapid degradation by oxytocinase (leucine aminopeptidase family enzymes) in plasma, kidney, and placenta. Subcutaneous half-life is estimated at 30–60 minutes due to slower depot absorption. FDA-approved only for obstetric use (IV infusion). Intranasal and subcutaneous uses for social/cognitive and off-label applications are not FDA-approved. Intranasal delivery provides partial CNS penetration via olfactory/trigeminal routes.

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See also: Full technical profile → All 45 compounds About the app