5-Amino-1MQ — Half-Life, Dosing & Protocol Guide

Also known as: NNMT inhibitor, 5-amino-1-methylquinolinium

Pharmacokinetics & Mechanism

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor with a rat oral half-life of approximately 5.0 hours and IV half-life of ~3.8 hours (Awosemo et al., J Pharm Biomed Anal 2021). Oral bioavailability in rats is ~38.4%. No human pharmacokinetic data exists. NNMT inhibition preserves intracellular nicotinamide (enabling more NAD+ via the salvage pathway) and SAM (S-adenosylmethionine). Kannt et al. (Sci Rep 2018) demonstrated reduced adiposity and improved glucose tolerance in diet-induced obese mice. No published human clinical trials as of 2026.

Track 5-Amino-1MQ in Halflife

The Halflife app models your 5-Amino-1MQ concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.