Insulin — Rapid Acting — Half-Life, Dosing & Protocol Guide

Also known as: Lispro / Humalog, Aspart / NovoLog, Glulisine / Apidra

Pharmacokinetics & Mechanism

Rapid-acting insulin analogs (lispro/Humalog, aspart/NovoLog, glulisine/Apidra) have SC half-lives of 42–81 minutes with onset 10–15 min, peak 45–90 min, and duration approximately 5 hours. B-chain amino acid mutations reduce insulin hexamer self-association, allowing faster SC monomer/dimer absorption. Lispro: B28Pro/B29Lys reversed. Aspart: B28Pro→Asp. Glulisine: B3Asn→Lys, B29Lys→Glu. All bind the insulin receptor → GLUT4 translocation and glucose disposal. Must be administered within 15 minutes of a meal to avoid pre-prandial hypoglycemia.

Track Insulin — Rapid Acting in Halflife

The Halflife app models your Insulin — Rapid Acting concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.