Insulin — Regular — Half-Life, Dosing & Protocol Guide

Also known as: Humulin R, Novolin R, Regular human insulin

Pharmacokinetics & Mechanism

Regular insulin (Humulin R/Novolin R) is native-sequence recombinant human insulin formulated with zinc to form hexamers in solution, slowing subcutaneous absorption. SC profile: onset ~30 minutes, peak ~3 hours, duration ~8 hours (per FDA NDA 018780). IV elimination half-life is approximately 4–6 minutes but downstream receptor signalling effects persist approximately 4 hours. Regular insulin is the only insulin formulation suitable for IV infusion in acute hyperglycaemia and DKA management. Must be administered 30 minutes before meals SC — unlike rapid-acting analogs which can be given immediately before or after eating.

Track Insulin — Regular in Halflife

The Halflife app models your Insulin — Regular concentration curve in real time — see exactly when your dose peaks, when it troughs, and how it overlaps with other compounds in your stack. All stored on-device, no account required.